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Home - Products - Angiogenesis - JAK - PF-06651600 malonate

PF-06651600 malonate

CAS No. 2140301-97-7

PF-06651600 malonate( PF06651600 malonate )

Catalog No. M13423 CAS No. 2140301-97-7

PF-06651600 malonate is a novel potent, selective JAK3 inhibitor with IC50 of 0.346 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-06651600 malonate
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-06651600 malonate is a novel potent, selective JAK3 inhibitor with IC50 of 0.346 nM.
  • Description
    PF-06651600 malonate is a novel potent, selective JAK3 inhibitor with IC50 of 0.346 nM, displays >1,000-fold selectivity over JAK1 and JAK2; inhibits Th1 and Th17 cell differentiation and function, reduces disease pathology in rat adjuvant-induced arthritis as well as in mouse experimental autoimmune encephalomyelitis models; selectively targets γc cytokine pathways while preserving JAK1-dependent anti-inflammatory signaling such as the IL-10 suppressive functions following LPS treatment in macrophages and the suppression of TNFα and IL-1β production in IL-27-primed macrophages.Rheumatoid Arthritis Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PF06651600 malonate
  • Pathway
    Angiogenesis
  • Target
    JAK
  • Recptor
    JAK
  • Research Area
    Inflammation/Immunology
  • Indication
    Rheumatoid Arthritis

Chemical Information

  • CAS Number
    2140301-97-7
  • Formula Weight
    389.412
  • Molecular Formula
    C18H23N5O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC1CCC(CN1C(=O)C=C)NC2=NC=NC3=C2C=CN3.C(C(=O)O)C(=O)O
  • Chemical Name
    1-[(2S,5R)-2-Methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-2-propen-1-one malonate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Telliez JB, et al. ACS Chem Biol. 2016 Dec 16;11(12):3442-3451. 2. Thorarensen A, et al. J Med Chem. 2017 Mar 9;60(5):1971-1993. 3. Robinette ML, et al. Mucosal Immunol. 2017 May 17. doi: 10.1038/mi.2017.38.
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